For nearly 60 years, the monoamine hypothesis has focused pharmacological treatment on the modulatory neurotransmitters serotonin, dopamine, and norepinephrine.1-3
Additional hypotheses suggest that other neurotransmitters may be involved in the pathophysiology of depression:
Learn about the relationship between earlier response to antidepressants and improved patient outcomes.
See how the challenges of depression management can negatively impact patient outcomes.
Re-examine depression. Follow us on the journey forward. Stay up-to-date on the science of depression.
Inhibitory and excitatory neurotransmission occur through the GABA and glutamate systems, respectively, affecting both intrinsic and extrinsic control of information flow in the brain.6,7
GABA=gamma aminobutyric acid.
Learn about the response rates and side effects of antidepressants.
Explore the relationship between early response to antidepressants and improved patient outcomes.
Sign up to receive the latest insights.