It’s time
to re-examine
depression

Actor portrayal.

Depression is a devastating and debilitating
disorder that affects millions of people in the US1-3

Take a look at the challenges patients suffering from major depressive disorder (MDD)
or postpartum depression (PPD) are still experiencing.
Explore major depressive disorder (MDD)

It’s time to re-examine how we think about the nature of the disorder and to what extent MDD impacts patients.

Re-examine MDD
Examine postpartum depression (PPD)

Learn how the burden of illness is distinct from MDD and how it can impact mothers and their babies.

Re-examine PPD

Looking beyond monoamines

Learn about the neurochemical systems, including excitatory and inhibitory signaling, that may play a role in depression.

MDD diagnosis to
treatment journey

Hear firsthand what it was like for Jeffrey living with MDD and the impact it has made on his daily life.

Early response to antidepressants may be a link to improved patient outcomes4,5

Scientific discoveries regarding the role of certain pathways, including inhibitory and excitatory signaling in the brain, may give us a different perspective on depression and its treatment.6

What’s the significance of early improvement in MDD?

Learn how early response to antidepressants may be a key to improved patient outcomes.

See the MDD data
Is there more behind depression than the monoamine hypothesis?

Learn about research that may offer new perspectives on MDD and PPD.

Review the science
Videos & resources

Explore videos about the pathophysiology of depression and download reference guides about the unmet needs for patients with MDD and PPD.

Check out resources

References: 1. World Health Organization. https://www.who.int/news-room/fact-sheets/detail/depression. Accessed January 3, 2023. 2. SAMHSA. 2021 NSDUH Detailed Tables. https://www.samhsa.gov/data/report/2021-nsduh-detailed-tables. Published January 4, 2023. Accessed February 8, 2023. 3. Data on file. PPD estimated prevalence, diagnosis, and treatment rate of postpartum depression in the United States. 2022. 4. Wagner S, Engel A, Engelmann J, et al. Early improvement as a resilience signal predicting later remission to antidepressant treatment in patients with major depressive disorder: systematic review and meta-analysis. J Psychiatric Res. 2017;94:96-106. 5. Ciudad A, Álvarez E, Roca M, et al. Early response and remission as predictors of a good outcome of a major depressive episode at 12-month follow-up: a prospective, longitudinal, observational study. J Clin Psychiatry. 2012;73(2):185-191. 6. Duman RS, Sanacora G, Krystal JH. Altered connectivity in depression: GABA and glutamate neurotransmitter deficits and reversal by novel treatments. Neuron. 2019; 102(1):75-90.

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